Possible Interaction: Glucose and Quercetin

“We conclude that humans absorb appreciable amounts of quercetin and that absorption is enhanced by conjugation with glucose.”

“In the X. … model, GLUT2‐mediated glucose and fructose … inhibited by quercetin , (−)‐epigallocatechin gallate (EGCG) and apigenin, GLUT5‐mediated fructose transport was inhibited by apigenin and EGCG, but not by quercetin, … GLUT7‐mediated uptake of both glucose and fructose was inhibited by apigenin, but not by quercetin nor EGCG.”

“In both Caco-2 and G6D3 cells, quercetin 4'-beta-glucoside uptake was inhibited by 30 mM glucose and 0.5 mM phloridzin.”

“After being combined with 20 μmol L⁻¹ of quercetin for 11 days, the fresh plasma with δ-glucose caused 323.05-32.07% inhibition of HGA formation in type II diabetes plasma proteins (TPP).”

“ Glucose significantly reduced the affinities of HPPs for 6-hydroxyflavone by 10.72 times, slightly weakened the affinities of HPPs for quercetin , 7-hydroxyflavone, and kaempferol, and hardly affected the affinities of HPPs for myricetin, chrysin, and 3,7-dihydroxyflavone on the first day.”

“ Glucose exit from human erythrocytes is inhibited by quercetin (Ki = 2.4 μm) but not anionic quercetin-semiquinone.”

“ Quercetin influx is retarded by extracellular d-glucose (50 mm) but not by phloretin and accelerated by intracellular d-glucose.”

“Graphical abstract Inhibitory mechanism of quercetin against glucose- , ribose-, and MGO-mediated AGE formation and structures of MGO-quercetin adducts were elucidated.”

“ Quercetin ingestion reduced postprandial glucose , NEFA, and TG concentration, but two hours after ingestion of the meal no effect on gastric emptying was observed.”

“ Quercetin , but not quercitrin moderately attenuated the effects of TNF-α and enhanced the basal and insulin stimulated uptake of glucose in a dose-dependent manner via the activation of the protein kinase B (Akt) and AMP-activated protein kinase (AMPK) pathways.”

“ Quercetin did not inhibit glucose transport into cells but decreased intracellular sequestration of [5- 3 H]glucose under conditions of net glucose release.”