Possible Interaction: Glucose and Pyruvic Acid

“The blood pyruvic acid levels after 60 and 90 minutes of glucose load were significantly higher in pellagrins as compared to controls.”

“ Pyruvic acid levels in blood (recorded in 15 patients) were significantly high in the fasting state as well as after glucose in these cases when compared to normal values.”

“Deficiency of thiamine leads eventually to elevated levels of lactate and pyruvate in the blood, though clinical symptoms may occur in the presence of normal fasting levels; in such cases the ingestion of glucose or participation in physical exercise may cause a demonstrable rise in blood pyruvic acid.'”

“Glyceraldehyde, pyruvic acid , 2‐ketoisocaproic acid, and 10 mM MgATP prevented the down‐regulation induced by 2.8 mM or less glucose.”

“ Pyruvic acid (PA), 2-ketovaleric acid (KV), 2-ketoisovaleric acid (KIV) or 2-keto-3-methylvaleric acid (KMV) dose-dependently promoted the stimulatory effects of D-glucose , whereas 2-ketobutyric acid (KB) did not affect insulin release.”

“Recent study reported that BTS significantly suppressed an increase in body weight and amounts of visceral fat and subcutaneous fat and serum concentrations of triglyceride, glucose , and hemoglobin A1c (HbA1c) in the mice fed with a high-fat diet as compared with the control group in 1 month [1].”

“In shaking-flask culture: (1) peptone of more than 20 g/L inhibited the accumulation of pyruvic acid; (2) production of pyruvic acid was increased from 23.5 g/L to 30.2 g/L by simply feeding glucose.”

“The intravenous infusion of glucose (0.5 g/kg/30 min) into normal dogs results in a rise in the blood pyruvic acid concentration, followed by a return to control levels in 90 minutes.”

“It is also relevant that according to Weil-Malherbe [1937] pyruvic acid is removed more effectively from brain slices in the presence of glucose than in its absence.”