Possible Interaction: Glucose and Propranolol

“The insulin resistance on both glucose production and utilisation was prevented by propranolol.”

“Pretreatment with metoclopramide or phentolamine did not block these effects, but pretreatment with propranolol significantly (P < 0.05) blunted the increase in fasting glucose and insulin levels.”

“… propranolol … glucose load in normal subjects.1 2 A group of maturity-onset diabetics tended to have higher blood sugars during chronic treatment with propranolol or … of these two drugs at two dosage levels on the oral glucose tolerance and insulin response of a group of maturity-onset diabetics.”

“Insulin secretion could be inhibited by propranolol after administration of glucose or SC.”

“Besides acting on mechanical parameters which help determine the balance of oxygen supply and oxygen demand in the ischaemic tissue, propranolol decreases the myocardial uptake of free fatty acids and increases that of glucose.”

“Treatment of cells with carvedilol, atenolol, and propranolol decreased levels of all 3 cytokines in cells exposed to either 5.5 or 27.5 mM dextrose.”

“ Propranolol , but not the other β-blockers, caused a significantly greater fall in glucose on exercise than during the control study.”

“Beta blockade with the use of propranolol impairs both hepatic glucose production and glucagon secretion mechanism.”

“When propranolol was given in addition during this beta-receptor stimulation, plasma GIP after glucose increased to 82.2 (49.7-145) pM and serum insulin to 61 (9-133) mU/l.”

“It is concluded that the non-selective beta-adrenoceptor antagonist propranolol inhibits the release of GIP after intraduodenal administration of glucose.”