Possible Interaction: Glucose and Propofol

“There are three important points in our experience: propofol should be avoided, dextrose infusion therapy should be continued to prevent metabolic decompensation, and liver transplant or other procedures should be avoided during metabolic decompensation.”

“CONCLUSIONS: Propofol has beneficial effects on 30 mM glucose –induced NO reduction and O2·− accumulation in human umbilical vein endothelial cells.”

“Furthermore, compared with … treatment, 30 mM glucose decreased the BH4 level (P = 0.0001) and guanosine triphosphate cyclohydrolase I expression (P < …), whereas it increased peroxynitrite level (P = 0.0003), which could all be reversed by propofol (P = 0.0045, P < 0.001, P = … vs 30 mM glucose treatment, respectively).”

“ Propofol reduced postload glucose levels after either intraperitoneal or oral administration of glucose in both 7- and 12-month-old rats, but not those at 2 months of age.”

“ Glucose and lactate concentrations were increased ( < 0.05) by Prop and Pent within the first hour of GA ( < 0.05).”

“In the … state, propofol increased glycogenolysis ( glucose release ), glycolysis (lactate and pyruvate production) and oxygen uptake in the range between 10 and 500 microM. In the liver of fasted rats, propofol up to 100 microM increased oxygen uptake but decreased gluconeogenesis from three different substrates: lactate, alanine and glycerol.”

“While MMB, Chloral, PTB, and PF showed ubiquitous reduction in the cerebral metabolic rates of glucose (CMR glu ) in brain regions, KX and IFL showed higher reductions in cerebellum and interbrain, and cerebellum, respectively.”

“Finally, we demonstrated that propofol specifically blocks Kv currents in β-cells, resulting in insulin secretion in the presence of glucose.”