Possible Interaction: Glucose and Prednimustine

“Twenty-four hours of glucose infusion increased the basal plasma glucose (5.1 +/- 0.1 to 6.4 +/- 0.2 mM, P = 0.001) and insulin (79 +/- 8 to 174 +/- 31 pM , P less than 0.05) levels.”

“Use of this assay indicated that, in lean nondiabetic subjects, glucose ingestion resulted in an increase (P < 0.001) in the plasma concentration of amylin (from 2.03 ± 0.22 to 3.78 ± 0.39 pM) and insulin (from 48.3 ± 3.1 to 265 ± 44 pM).”

“Intravenous administration of 10 g glucose (n = 7) also caused a significant increase in plasma IAPP from 5.0 ± 0.4 to 11.6 ± 0.9 pM (P < 0.01) 5 min after injection.”

“Rats treated with glucose (500 mg/kg bw) for 30 days showed a 146%, 183%, 208%, and 177% (P < 0.05) increase in 5‐HT levels in ST, PM , CB, and CCX, respectively.”

“Plasma GLP-1, … levels 30 min postoral glucose were significantly higher in the 30% fiber group vs. the 0% group (19.8 +/- 1.2 vs. 15.4 +/- 1.….67 +/- 0.4 vs. 1.29 +/- 0.5 ng/ml, and 964.4 +/- 94.4 vs. 530.2 +/- 120.4 pM, …).”

“Low insulin concentrations (3 pM ) stimulated ICM and TE development in the presence of 1.1 or 6 mM glucose.”

“TGF-beta (500 pM ) counter-acted the mitogenic action of 16.7 mM glucose but failed to affect the glucose-induced increase in islet insulin content or secretion.”

“The insulin response to 5.5 or 16.7 mM glucose was markedly enhanced by 750 pM porcine VIP and a concentration of 250 pM was still effective.”