Possible Interaction: Glucose and Polyunsaturated Fatty Acids

“Importantly, these ω‐6 PUFAs attenuated the short lifespan of glucose‐fed lpin‐1‐inhibited animals.”

“ Glucose also increased the level of reactive oxygen species, which promoted the peroxidation of these PUFAs to generate 4-hydroxy-2E-nonenal (4-HNE).”

“CONCLUSIONS Excess glucose and SFAs regulate chemotactic factor expression by a mechanism that involves ROS generation, NFκB, and PPARγ, and which is repressed by PUFAs.”

“Our initial studies indicated that the induction ofSREBP-1 expression by insulin and glucose was blocked by PUFA.”

“They exercise this effect by modulating the expression of genes coding for key metabolic enzymes and, in doing this, PUFA govern the intracellular as well as the interorgan metabolism of glucose and fatty acids.”

“Alterations in the ratio of polyunsaturated to saturated fatty acids in the diet modifies the age-associated changes in the intestinal uptake of glucose.”

“The suppression of gene … the addition of PUFA to a high carbohydrate diet: occurs quickly (< …) after its addition to a high glucose diet ; can be recreated with hepatocytes cultured in a serum-free medium containing insulin …; can be demonstrated in diabetic rats fed fructose; and is independent of glucagon.”

“In contrast, when islets were perifused with PUFA in the presence of 27.7 mM glucose , PUFA-induced insulin release was observed.”

“These results suggest that diets enriched with PUFA enhance peripheral glucose utilization significantly more than diets comprised of MUFA or SFA sources.(ABSTRACT TRUNCATED AT 250 WORDS)”

“Thus, (1) … the polyunsaturated fatty acid diet diminishes the enhanced … and ileal uptake of glucose in diabetic rats, and (2) the influence of the polyunsaturated fatty acid diet on uptake in diabetic … was not explained by alterations in intestinal morphology or brush-border membrane content of cholesterol or phospholipids.”