Possible Interaction: Glucose and Polypeptides

“Reactions of polypeptides with glucose resulting in advanced glycation end products (AGE) generation and reaction with lipid peroxidation products giving advanced lipoxidation end products (ALE) and mechanisms of the above products generation are described.”

“Labeling of the 52,000-dalton polypeptide was more sensitive than that of the 46,000-dalton polypeptide to inhibition by the presence of D-glucose.”

“Also oral administration of 75g glucose elicited an exaggerated rise in plasma PP in the IGT and DM groups when compared with the response in the control and NGT groups.”

“ Oral glucose … PP from 19.3 (4.2-37.0) to 61.1 (14.1-141.7) pM. Isoprenaline increased the PP concentration from 13.5 (… oral glucose to 77.5 (25.3-134.7) pM. The increase in PP concentration was eliminated when propranolol was added to isoprenaline.”

“Oral administration of 50g of glucose elicited an exaggerated rise in plasma PP in diabetic patients as compared with the response in normal subjects.”

“Incorporation of zone 4.5 polypeptides into bilayer lipid membranes increases their permeability to D-glucose at 27 and 5 degrees C. 5.”

“The OR not IP administration of glucose had significant effects on the gene expressions of preprovasoactive intestinal peptide, pituitary adenylate cyclase activating polypeptide and gastrin in intestine.”

“The UDP-glucose:glycoprotein glucosyltransferase (UGT1, UGGT, GT) monitors the folding state of polypeptides released from calnexin and adds back a glucose residue on N-glycans of nonnative polypeptides , thereby prolonging retention in the calnexin chaperone system for additional folding attempts.”

“Exposure of cells to glucose increased the RL2 signal on several polypeptides , but this change could be blocked by inhibition of GFAT.”

“In contrast, glucose (EC50 approximately 6 mM), but not 3-O-methylglucose or fructose, prevents the glucose-deprivation-induced accumulation of total GLUT-1 polypeptides.”