Possible Interaction: Glucose and Pimagedine

“Amongst the products tested are aspirin and aminoguanidine which compete with glucose for the same protein amino group.”

“ Aminoguanidine partially prevented the glial alterations induced by the 12 mM glucose medium.”

“Both thiamine and aminoguanidine corrected reduced pericyte viability when added to high D-glucose.”

“Both thiamine and aminoguanidine restored impaired pericyte adhesion when added to high d-glucose and high d-galactose, but not l-glucose.”

“ Aminoguanidine and insulin can reduce contents of glucose and AGE in diabetic skin tissue, and ameliorate diabetic cutaneous neuropathy.”

“At concentrations lower than 18 mmol/l, the unexpected increase in pentosidine formation may result from a reaction of aminoguanidine with (i) auto-oxidation products of glucose (arabinose or glyoxal [10]), and (ii) with two accessible lysines and/or hydroxylysines at a suitable distance to form pentosidine.”

“ Replacing glucose with ribose showed a quicker increase in cross-linking and less effect on cross-linking by adding aminoguanidine , demonstrating the higher reactivity of pentoses above hexoses.”

“CML was also formed when glucose , preincubated with ONOO(-), was incubated with HSA but was completely inhibited by aminoguanidine , a trapping reagent for alpha-oxoaldehydes.”

“These results suggest that AG at high concentrations impairs pancreatic B-cell response to a high concentration of glucose.”

“Incubation of Aminoguanidine with albumin produced the appearance of 320 nm absorbing yellow chromophores, quite increased in the presence of glucose.”