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Last Updated: 2 years ago

Possible Interaction: Glucose and Physostigmine

supplement:

Glucose

Research Papers that Mention the Interaction

Low subeffective doses of the central acting anticholinesterase physostigmine (35 micrograms/kg, ip), administered immediately after training, and glucose (10 mg/kg, ip), given 10 min after training, acted synergistically to improve retention.
Behavioral and neural biology  •  1994  |  View Paper
Glucose (100 mg/kg) significantly facilitated the onset of tremors when injected before either dose of physostigmine , and augmented (at 100 and 250 mg/kg) tremor severity when injected before the lower dose of physostigmine.
The present study examined whether glucose would augment behavioral effects produced by a muscarinic agonist, physostigmine.
Behavioral and neural biology  •  1988  |  View Paper
Physostigmine apparently increases the permeability of the blood-brain barrier to barbiturates and acid fuchsin (Greig & Holland, 1949; Greig & Mayberry, 1951; Greig & Carter, 1954; Beiler, Brendel & Martin, 1956) and decreases it to glucose (Greig & Gibbons, 1959).
The Journal of physiology  •  1961  |  View Paper
Replacement of potassium in human cells during metabolism of glucose is similarly blocked by physostigmine , which is considered to be a specific inhibitor of cholinesterase activity.
Archives of biochemistry and biophysics  •  1953  |  View Paper