Possible Interaction: Glucose and Physostigmine

“Low subeffective doses of the central acting anticholinesterase physostigmine (35 micrograms/kg, ip), administered immediately after training, and glucose (10 mg/kg, ip), given 10 min after training, acted synergistically to improve retention.”

“ Glucose (100 mg/kg) significantly facilitated the onset of tremors when injected before either dose of physostigmine , and augmented (at 100 and 250 mg/kg) tremor severity when injected before the lower dose of physostigmine.”

“The present study examined whether glucose would augment behavioral effects produced by a muscarinic agonist, physostigmine.”

“ Physostigmine apparently increases the permeability of the blood-brain barrier to barbiturates and acid fuchsin (Greig & Holland, 1949; Greig & Mayberry, 1951; Greig & Carter, 1954; Beiler, Brendel & Martin, 1956) and decreases it to glucose (Greig & Gibbons, 1959).”

“Replacement of potassium in human cells during metabolism of glucose is similarly blocked by physostigmine , which is considered to be a specific inhibitor of cholinesterase activity.”