Possible Interaction: Glucose and Phospholipids

“Stimulation with concentrations of glucose and carbachol that accelerate hydrolysis of endogenous AA from islet phosphoplipids also results in accelerated Kv2.1 inactivation and a shorter time-to-peak current interval.”

“ Glucose and reactive oxygen species (ROS), such as the hydroxyl radical (•OH), can react with APL leading to an array of oxidised, glycated and glycoxidised derivatives.”

“However, glucose can also react with primary amino groups present in other cellular components, such as aminophospholipids (aminoPLs).”

“Plasma PL C22:6n-3 was significantly lower in case group than in control group, and was negatively correlated with fasting glucose (r = −0.177, p < 0.001).”

“Lipid-linked AGEs form readily in vitro by the covalent addition of glucose to the amine-containing head groups of phospholipids.”

“ Glucose , hydrocortisone or verapamil have also been shown to inhibit the release of mesothelial phospholipids.”

“ Phospholipid asymmetry in erythrocytes treated … concentrations of glucose (> 5 mM) showed a time-dependent (t1/2 approximately 12 h) and concentration-dependent (half-maximal concentration approximately 7.5 mM) … in the accessibility of PS and PE, and a decrease in the accessibility of SM and PC, to exogenous phospholipases.”

“The unsaturation index of serum phospholipids significantly correlated with glycosylated hemoglobin A1c (P less than .05) and blood glucose levels after glucose load (P less than .001).”

“The capacity of phospholipids to do so is limited and markedly inhibited by glucose and sorbitol.”

“However, the percentage of incorporation of glucose into phospholipids was higher than those observed from lactate or 3-HB.”