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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glucose
supplement:
Phosphatidic Acid
Research Papers that Mention the Interaction
“We now show, for the first time, that glucose and carbachol, at concentrations which stimulate insulin secretion, significantly increase endogenous phosphatidic acid levels in pancreatic islets by 2-fold at 1 min, nearly 3-fold at 2 min, and over 3-fold at 30 min compared to control.”
Glucose and carbachol synergistically stimulate phosphatidic acid accumulation in pancreatic islets.“In both cases, glucose increased the 32P content of phosphatidic acid (PA), phosphatidylinositol (PI), and polyphosphoinositides (PPI).”
“In islets prelabeled with [32P]Pi, 15-min stimulation with glucose (16.7 mM) caused increased labeling of phosphatidic acid (93%) and phosphatidylinositol (94%) and decreased labeling of the polyphosphoinositides (20%).”
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