Possible Interaction: Glucose and Phenytoin

“Thus, the tendency of DPH to impair the insulin response to glucose has been confirmed in this controlled study.”

“ DPH treatment for 3 days with a dose of 300 mg/die (100 mg, 3 times daily) significantly decreased the insulin release after glucose ingestion , but did not alter the basal insulin level.”

“The knowledge that DPH has the property of reducing CMRO2, the lactates production and of increasing the cerebral level of glucose , glycogen and phosphocreatinine, has persuaded us to use this drug instead of barbiturate, as a therapeutic protection to prevent hypoxic damages to the nervous cell.”

“With a standard oral dose of DPH all subjects showed a reduced insulin response to oral glucose (11–44%).”

“It has been found that diphenylhydantoin alters the insulin secretion following a glucose load.”

“Combining glucose with diazepam and phenytoin significantly decreased post-treatment seizures, but not mortality.”

“ DPH suppressed ATP content and mitochondrial membrane hyperpolarization in the presence of 16.7 mm glucose without affecting glucose utilization, glucose oxidation, and reduced nicotinamide adenine dinucleotide phosphate fluorescence.”

“An increase in extracellular Ca from 2.5 to 5.0 mM attenuated the inhibitory effect of phenytoin oh both the metabolic and secretory responses to glucose and veratridine.”

“However, ouabain together with phenytoin almost completely blocked glycolytic flux measured in the presence of either glucose or veratridine.”

“The increase in insulin release induced by 16.7 mM glucose or 200 μM veratridine was inhibited 77% and 60%, respectively, by 100 μM phenytoin , whereas the increase in the rate of glycolysis was inhibited 74% and 100%, respectively.”

“ DPH sequentially suppressed early response to a series of two, short, glucose pulses.”

“Exposure to DPH prior to glucose further inhibited the first phase, and increasing the dose had no additional effects, whereas only raising the diazoxide dose intensified inhibition of early release.”

“ DPH completely inhibited the immunoreactive insulin response to glucose.”