Possible Interaction: Glucose and Phenylalanine

“Na+-coupled transport of glucose and phenylalanine decrease in linear proportion to PDpt.”

“However, the plasma glucose area response was decreased 66% when phenylalanine was co-ingested with glucose.”

“When glucose was ingested with phenylalanine , the circulating phenylalanine, glucagon, AAN, and insulin area responses were approximately the sum of the responses to phenylalanine alone and glucose alone.”

“Systemic phenylalanine appearance decreased from 40.3 +/- 1.9 to 37.0 +/- 1.6 mumol/min during glucose infusion (P < 0.05).”

“ Glucose infusion increased the hepatic lysine and valine uptake and decreased phenylalanine uptake.”

“Insulin release due to glucose (20 mM) was temporarily inhibited by phenylalanine.”

“Thus, D-glucose increases in a rapid, sustained, and dose-related manner the incorporation of [3H]leucine or [3H]phenylalanine into trichloroacetic acid-precipitable material; there is a 7-fold difference between basal and glucose-stimulated protein biosynthesis.”

“The absorbance changes associated with simultaneous addition of d-glucose and l-phenylalanine were additive.”

“Methionine and phenylalanine release was also stimulated by glucose.”

“In both species, glucose alone, like other transportable sugars, inhibits phenylalanine uptake.”

“These results reveal the interplay between two effects of glucose on phenylalanine transport in the rat intestine, namely the interaction between sugar and amino acid transports at the level of the luminal membrane, and the production of energy by intracellular glycolysis.”

“Plasma concentrations of valine, isoleucine, leucine and phenylalanine were depressed to 57, 71, 89 and 90% of their control values during glucose , propionate, butyrate and acetate infusion.”