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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glucose
drug:
Phentolamine
Research Papers that Mention the Interaction
“In diabetics, acute insulin responses to glucose were significantly increased by all the agents tested (naloxone, phentolamine and lysine acetylsalicylate), but only the cyclooxygenase inhibitor significantly augmented second phase insulin secretion and glucose disappearance rates.”
Impaired insulin secretion in human diabetes mellitus. Interactions between naloxone, phentolamine and lysine acetylsalicylate upon glucose induced insulin release.“Alpha blockade with intravenous (IV) phentolamine (n = 5) infusion increased oxygen consumption after glucose ingestion but no more than it increased the oxygen consumption when no glucose was given.”
“Glucose-stimulated insulin concentrations were unchanged by propranolol and combined blockade, whereas there was a trend (P = 0.07) toward an increased response to glucose during phentolamine administration.”
“ Glucose mediated insulin release from isolated islets was enhanced by phentolamine and decreased by propranolol.”
Ethanol influence on insulin secretion from isolated rat islets“Pretreatment with the α-adrenoceptor blocking agents, phentolamine and dihydroergotamine, blocked the increase of the plasma level of glucose induced by dopamine, whereas the hyperglycaemic effect of 7-(3-methyl)-propyl-theophylline-dopamine was better antagonized by the β-adrenoceptor blocking agent, propranolol.”
“3 Modulation of cytosolic [Ca2+]i by efaroxan and phentolamine was augmented by glucose (5–10 mM) which both potentiated the magnitude of the response and reduced the onset time of imidazoline‐induced rises in [Ca2+]i.”
“Intravenous administration of the alpha-blocker phentolamine led to a reduction in glucose and a substantial increase in insulin levels.”
“ Phentolamine , propranolol, and combined blockade reduced glucose absorption after oral glucose.”
“An alpha-blockade with phentolamine (2 mg/kg, iv) resulted in diminished release of GL by approximately 50% (P less than 0.05) and reduced hepatic arterial vasoconstriction by approximately 47% (P less than 0.01) upon stimulation (8 Hz, 5 min), even though NA release was markedly enhanced.”
“In spring and summer, insulin secretion induced by glucose is enhanced after in vivo and in vitro phentolamine treatment.”
“The reduced fetal consumption and increased production of glucose was inhibited by phentolamine but not by propranolol.”
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