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“The depression in cerebral glucose metabolic rate due to phenobarbital , if confirmed, may have bearing on the adverse neuropsychological effects of the drug.”
British journal of clinical pharmacology • 1986 | View Paper
“Enhanced reactivity of beta-NH2 terminus of Hb with glucose , was partly explained by observing that its pKa was decreased in the presence of PB.”
“In samples of Hb exposed to glucose in vitro in the presence of PB , HbA1c was also found to be significantly higher than in those exposed to glucose in the absence of PB.”
“Whole brain glucose utilization declined in a dose-related manner by 4%, 13%, 33%, 35%, and 56% after phenobarbital 18, 60, 180, 300, and 600 mg/kg, respectively.”
“Injection of …/kg of phenobarbital to adult mice resulted in the decrease … rates of use of phosphocreatine, ATP, glucose and glycogen in brain, and the cerebral metabolic rate was estimated to be 12.8 …/g/min in terms of the use-rate of high energy phosphate equivalents (approximately P).”
Archives internationales de pharmacodynamie et de therapie • 1979 | View Paper
“It was reported (LOWRY, PASSONNEAU, HASSELBERGER and SCHULZ, 1964) that the level of brain glucose was higher in phenobarbitone-treated mice than in control animals.”