Possible Interaction: Glucose and Phenobarbital

“The depression in cerebral glucose metabolic rate due to phenobarbital , if confirmed, may have bearing on the adverse neuropsychological effects of the drug.”

“ Phenobarbitone (50 mg for 10 days) increased M (30%), metabolic clearance rate of glucose (MCRg), and antipyrine clearance rate (33%).”

“Enhanced reactivity of beta-NH2 terminus of Hb with glucose , was partly explained by observing that its pKa was decreased in the presence of PB.”

“In samples of Hb exposed to glucose in vitro in the presence of PB , HbA1c was also found to be significantly higher than in those exposed to glucose in the absence of PB.”

“An increase of phenobarbital dose enhanced and prolonged its effect on the renal tubular transport of glucose.”

“ Phenobarbital (10 mg/kg) given orally for 8-10 days reduced the tubular reabsorption of glucose in dogs.”

“Addition of phenobarbital augmented the number of foci 3-fold in the sucrose group and 5-fold in the glucose group.”

“Whole brain glucose utilization declined in a dose-related manner by 4%, 13%, 33%, 35%, and 56% after phenobarbital 18, 60, 180, 300, and 600 mg/kg, respectively.”

“Injection of …/kg of phenobarbital to adult mice resulted in the decrease … rates of use of phosphocreatine, ATP, glucose and glycogen in brain, and the cerebral metabolic rate was estimated to be 12.8 …/g/min in terms of the use-rate of high energy phosphate equivalents (approximately P).”

“It was reported (LOWRY, PASSONNEAU, HASSELBERGER and SCHULZ, 1964) that the level of brain glucose was higher in phenobarbitone-treated mice than in control animals.”