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Last Updated: 2 years ago

Possible Interaction: Glucose and Phenobarbital

supplement:

Glucose

Research Papers that Mention the Interaction

The depression in cerebral glucose metabolic rate due to phenobarbital , if confirmed, may have bearing on the adverse neuropsychological effects of the drug.
Neurology  •  1986  |  View Paper
Phenobarbitone (50 mg for 10 days) increased M (30%), metabolic clearance rate of glucose (MCRg), and antipyrine clearance rate (33%).
British journal of clinical pharmacology  •  1986  |  View Paper
Enhanced reactivity of beta-NH2 terminus of Hb with glucose , was partly explained by observing that its pKa was decreased in the presence of PB.
In samples of Hb exposed to glucose in vitro in the presence of PB , HbA1c was also found to be significantly higher than in those exposed to glucose in the absence of PB.
Farmaco  •  1994  |  View Paper
An increase of phenobarbital dose enhanced and prolonged its effect on the renal tubular transport of glucose.
Phenobarbital (10 mg/kg) given orally for 8-10 days reduced the tubular reabsorption of glucose in dogs.
Farmakologiia i toksikologiia  •  1990  |  View Paper
Addition of phenobarbital augmented the number of foci 3-fold in the sucrose group and 5-fold in the glucose group.
Cancer research  •  1985  |  View Paper
Whole brain glucose utilization declined in a dose-related manner by 4%, 13%, 33%, 35%, and 56% after phenobarbital 18, 60, 180, 300, and 600 mg/kg, respectively.
Anesthesiology  •  1985  |  View Paper
Injection of …/kg of phenobarbital to adult mice resulted in the decrease … rates of use of phosphocreatine, ATP, glucose and glycogen in brain, and the cerebral metabolic rate was estimated to be 12.8 …/g/min in terms of the use-rate of high energy phosphate equivalents (approximately P).
Archives internationales de pharmacodynamie et de therapie  •  1979  |  View Paper
It was reported (LOWRY, PASSONNEAU, HASSELBERGER and SCHULZ, 1964) that the level of brain glucose was higher in phenobarbitone-treated mice than in control animals.
Journal of neurochemistry  •  1966  |  View Paper