Possible Interaction: Glucose and Phenformin

“In the article that the authors refer to, Wingate and Hadley have shown that phenethylbiguaride added to the mucosal solution in isolated human ileal segments significantly inhibited mucosal glucose uptake and abolished glucose transport to the serosa.”

“It is shown that phenethylbiguanide significantly accelerates the turnover of glucose in the nondiabetic subject.”

“Arterial infusion of phenformin (1-0 mg-ml-1) produced less inhibition of glucose and water absorption.”

“Abstract In isolated perfused rat liver, phenethylbiguanide inhibits the rate of glucose production from both lactate and dihydroxyacetone, but not from xylitol.”