Possible Interaction: Glucose and Pentoxifylline

“Administration of pentoxifylline , an adenosine receptor antagonist, inhibits transiently endogenous glucose production in healthy humans without any changes in glucoregulatory hormone concentrations.”

“Furthermore, pentoxifylline also led to significant reduction in BMI (WMD=−0.51; 95% CI: −0.96, −0.06) and fasting glucose (WMD=−8.97; 95% CI: −14.52, −3.42), but did not significantly affect the serum tumor necrosis factor &agr; and adiponectin levels when compared with placebo.”

“Additionally, infinite-cis exit assays (Sen-Widdas assays) showed that only pentoxifylline disturbed d-glucose for binding to the exofacial substrate site.”

“Because pentoxifylline inhibited glucose production in the absence of any changes in concentrations of glucoregulatory hormones, we conclude that pentoxyifylline inhibits hepatic glucose production through other mechanisms, e.g., by blocking the adenosine receptor.”

“ Pentoxifylline infusion resulted … distribution for glucose 40 ml/kg) to approximately 46% (volume of distribution for glucose 165 ml/kg) decrease in basal glucose production within approximately 1 … in the control experiment glucose production declined by only approximately 4% in this time interval (P < 0.03 pentoxifylline vs. control).”

“It is possible that some of the therapeutic effects of pentoxifylline can be related to the facilitation of red blood cell membrane permeability for glucose.”

“b) The reductive effect of PTX on the activity of this enzyme was significantly attenuated when hypophosphatemia was increased in severity by administration of glucose. (”