supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Glucose
drug:
Pentobarbital
Research Papers that Mention the Interaction
“ Pentobarbital (2 mM) decreased the deltaV++ of net glucose exit into glucose-free solution from 30 +/- 5 ml mol(-1) (control) to 2 +/- 0.5 ml mol(-1) (P < 0.01).”
Effects of High Pressure on Glucose Transport in the Human Erythrocyte
“On cooling from 45 degrees …, in the presence of pentobarbital (…, glucose ) decreases from 30.6+/-7.8 mM to 14+/-1.9 mM; whereas in control cells, Ki (sorbose, glucose) ….3 mM at 45 degrees C to 23.4+/-4.5 mM at 30 degrees C (P<0.002).”
“ Pentobarbital (8 mM) increases the activation energy of glucose exit from control 54.7+/-2.5 kJ/mol to 114+/-13 kJ/mol (P<0.01).”
“ Pentobarbital acts as a mixed inhibitor of net D-glucose exit, as monitored photometrically from human red cells.”
“ Pentobarbital reduces the temperature coefficient of D-glucose binding to the external site.”
“The simultaneous administration of glucose and pentobarbital resulted in a longer period of anesthesia than did the injection of pentobarbital alone.”
“It was found that Hif1a and Tnfa were significantly overexpressed in the studied organs and serum AST, glucose , creatinine and urea levels were significantly increased after sodium pentobarbital overdoses (100 and 150 mg/kg) compared to 50 mg/kg dose.”
Sodium pentobarbital dosages for exsanguination affect biochemical, molecular and histological measurements in rats“However, euthanasia by an overdose of pentobarbital (120 mg/kg intraperitoneal injection) increased the serum levels of glucose , and decreased cholesterol, stearic and arachidonic acids levels compared with euthanasia by CO2 inhalation and decapitation.”
“In addition, pretreatment with pentobarbital resulted in a 75% increase in the endogenous concentration of glucose , 10% increase in glucose 6-phosphate, no change in fructose 6-phosphate and 42% decrease in lactate compared to levels in brains obtained from conscious animals.”
“ Sodium pentobarbitone produced a decrease in both rCBF and glucose , whereas chloral hydrate caused a decrease in glucose but an increase in rCBF.”
“The 3-MG results fit a model in which both the half-saturation constant and the maximal velocity of the glucose carrier are decreased by pentobarbital.”
“The administration of glucose to rats for 48 h resulted in an increase in the duration of anesthesia produced by intraperitoneal injection of pentobarbital.”
“However, in the fasted case pentobarbital completely prevented the 10-fold elevation of fructose 2,6-bisphosphate brought about by 30 mM glucose.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback