Possible Interaction: Glucose and Pancreatic Polypeptide

“RESULTS—Amylin and pancreatic polypeptide levels increased 15 min after a 75-g glucose load and remained elevated at 60 and 120 min (P < 0.0001).”

“… glucose infusion both depressed the … reduced the human pancreatic polypeptide response to the ingestion of a protein-rich meal (areas above pre-meal value: 19.5±4.1 (mean ± SEM) … caerulein infusion (areas above pre-caerulein value: 8.8±2.2 vs. 4.6±1.4, p < 0.01).”

“The stimulation of pancreatic polypeptide after oral glucose was significantly lower postoperatively (p < 0.01).”

“ Rat PP also inhibited the flow rate and amylase output increased by either 25 mM glucose alone or exogenous insulin alone.”

“ Rat PP , given intra‐arterially at a concentration of 10 pM, completely abolished the potentiation effects of both the 25 mM glucose and the exogenous insulin on the CCK‐stimulated flow rate and amylase output.”

“Sustained glucose infusion was necessary to decrease APP levels from normal fed levels of 8-10 to 4-5 ng/ml within 3-5 min; bolus injection was without effect on APP levels even though plasma glucose levels reached 730 mg/dl.”

“During stimulation of these two hormones by acetylcholine and the octapeptide of cholecystokinin intravenous infusion of glucose elicited a significant decrease of somatostatin levels by 30 pg/ml and of pancreatic polypeptide levels by 300 pg/ml.”