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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Glucose
supplement:
Palmitic Acid
Research Papers that Mention the Interaction
“These effects of PA were associated with significant increases in D-glucose and L-glutamine consumption as well as nitric oxide and ammonia production.”
Arachidonic acid, palmitic acid and glucose are important for the modulation of clonal pancreatic beta-cell insulin secretion, growth and functional integrity.“We found that 25mM of glucose and 0.4mM of palmitic acid treatment significantly increased cell apoptosis and impaired insulin secretion in INS‐1 cells.”
AMPK α1 mediates the protective effect of adiponectin against insulin resistance in INS‐1 pancreatic β cells“Subsequent to increasing glucose from 3 to 20 mM, PA caused small increases in OCR and cytosolic calcium (about 20% of the effect of glucose).”
“ Glucose promotes the synthesis of palmitic acid and stearic acid.”
“Both oleic acid (monounsaturated, long chain) and palmitic acid (saturated, long chain) also increased glucose production , whereas caproic acid (saturated, short chain) failed to increase glucose production.”
“In the presence ….7 mmol/l glucose protein production of p47phox was increased by 1.7-fold in isolated rat … 1 h, while in the presence of 0.1 mmol/l palmitic acid or 5 ng/ml IL-1β it was … 1.4-fold or 1.8-fold, respectively.”
“We evaluated several aspects of the insulin resistance induced by palmitic acid in rats and found that after treatment with 0.09 g/kg of palmitic acid there is a delay in the curve of tolerance to glucose.”
“Increasing concentrations of glucose promoted beta-cell proliferation that was dramatically reduced by palmitic acid.”
“These findings suggest that palmitic acid stimulates incorporation of glucose in the adipocyte by a mechanism dependent upon intracellular but not extracellular Ca2+.”
“Both glucose and cycloheximide activated biosynthesis of palmitic and oleic acids of glycerolipids and inhibited the arachidonic acid synthesis.”
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