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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“ Glucose and palmitate synergistically stimulate insulin secretion, but chronically elevated they induce apoptotic β-cell death.”
Palmitate and insulin counteract glucose-induced thioredoxin interacting protein (TXNIP) expression in insulin secreting cells via distinct mechanisms“In combination with high glucose, palmitate induced increased shunting of excess glucose , increased mitochondrial reactive oxygen species production and an elevation in many transcription-related proteins.”
“In INS-1 β-cells, 0.4 mM palmitate with 5 mM glucose increased the levels of dihydrosphingosine and dihydroceramides, two lipid intermediates in the de novo biosynthesis of ceramides, without inducing apoptosis.”
“Reduction of plasma FFA levels in fasted rats or humans severely impairs glucose-induced insulin release but palmitate can augment insulin release in the presence of nonstimulatory concentrations of glucose.”
“We recently showed that palmitate augments insulin release in the presence of non-stimulatory concentrations of glucose.”
“In contrast, palmitate significantly inhibited the stimulatory effects of 16.7 mmol/L glucose on insulin mRNA levels after 2, 3, and 7 days.”
“Treatment with palmitate increased glucose production by 50% in HepG2 cells.”
“The beta-oxidation of palmitate was decreased at 30 mmol/L glucose.”
“Even 0.05 mM PA and 2.5 mM glucose significantly reduce glucose and PA oxidation (P < 0.05), respectively.”
“The apoptotic percentage of endothelial cells treated with high levels of glucose plus FFAs was significantly higher than that treated with high concentration of glucose or FFAs ( PA and/or OA) alone.”
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