Possible Interaction: Glucose and Ornithine

“5 L‐Arginine (… mM) and L‐ornithine (5 mM) in the … of 5 mM glucose induced monophasic β cell responses which were both significantly reduced by SNP at 3 nM but not at 30 nM; in contrast, the L‐ornithine effect was significantly increased by SNP at 3 μm.”

“Thus, ornithine and/or NH4Cl seem to inhibit lactate to glucose flux by shifting the mitochondrial partitioning of pyruvate from carboxylation towards decarboxylation with the result of a decreased oxaloacetate formation.”

“The inhibitory effect of glucose on the postnatal rise in ornithine transcarbamylase activity might be due to the resulting insulin release.”

“ D-Glucose uptake rates were inhibited by 30 mu Lornithine and by 30 mn 3-o-methyl-o-glucose, but not by 30 mn L-glucose.”

“These enzymes could be coincidentally induced by arginine or ornithine to a very high level and their synthesis could be repressed by the addition of glucose , clearly demonstrating catabolite repression control of the arginine degradative pathway.”