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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glucose
drug:
Olanzapine
Research Papers that Mention the Interaction
“ Glucose , insulin, the insulin resistance index and the CRP levels significantly increased after olanzapine.”
Similar frequency of abnormal correlation between serum leptin levels and BMI before and after olanzapine treatment in schizophrenia“Taken together, these data show that olanzapine dysregulates glucose and lipid metabolism and exacerbates hepatic changes caused by eating a HFD.”
“We found that olanzapine led to an increase in the acute insulin response to glucose , which was not seen with placebo, and was attenuated in the olanzapine group by atropine.”
“However, olanzapine induces weight gain and dysfunction of glucose and lipid metabolism significantly, which is associated with increased risk of complications.”
“We therefore suggest that a single dose of OLA may invoke early changes in some parameters of glucose and lipid metabolism, as well as endocrine indices.”
“ Olanzapine increased glucose Area Under the Curve (AUC) by 42% (2808±474 vs. 3984±444 mg/dl·min; P = 0.0105) during an oGTT.”
“ Olanzapine was also associated with a higher increase of glucose (n=406, 2 RCTs, MD -7.30 CI -7.62 to -6.99).”
“ Olanzapine produced more increase in glucose than amisulpride, aripiprazole, quetiapine, risperidone and ziprasidone; no difference was found with clozapine.”
“Clozapine and olanzapine seem to have the greatest potential to induce glucose and lipid metabolism abnormalities, and risperidone has the least.”
“While effective in reducing psychoses, OLZ causes rapid impairments in glucose and lipid homeostasis.”
Voluntary physical activity protects against olanzapine-induced hyperglycemia.
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