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Last Updated: a year ago

Possible Interaction: Glucose and Octreotide



Research Papers that Mention the Interaction

CONCLUSIONS Oc reotide ab olishes the early and diminishes the late GLP-1 and insulin responses to oGT T an d St-M in NFA and GHA patients and in healthy subjects.
During the oGTT, octreotide initially almost abolished the early (0-60 min) and diminished the late (60-180 min) GLP-1 and insulin responses in patients and healthy subjects.
European journal of endocrinology  •  1999  |  View Paper
Octreotide completely abolished the immediate insulin response to glucose in all subjects (both P < 0.0001) and caused a delayed and significantly increased glycaemic response in both groups (P < 0.0001).
Clinical science  •  1998  |  View Paper
The time required for recovery … hypoglycaemia was longer after octreotide (19.1 +/- 1.2 min vs 14.3 +/- 0.9 min, p < 0.05), and a greater amount of infused glucose was needed to reach normoglycaemia (g 24.6 +/- 1.2 vs 17.7 +/- 1.3, p < 0.05).
Diabetes & metabolism  •  1997  |  View Paper
Following octreotide, glucose disposal (7.33 +/- 0.49 v 6.08 +/- 0.55 mg/kg/min, P < .05) increased and hepatic glucose production (HGP) was more suppressed (-1.56 +/- 0.07 v -0.63 +/- 0.34 mg/kg/min, P < .05, 220 to 270 minutes).
Metabolism: clinical and experimental  •  1996  |  View Paper
Orthostatic pulse increases after glucose decreased from 36 +/- 6 beats/min after placebo to 9 +/- 5 beats/min after octreotide (P < .05), and standing blood pressure decreases after glucose were abolished (P < .05), but octreotide had no effect on increase in hematocrit or plasma osmolarity after glucose.
The Journal of pharmacology and experimental therapeutics  •  1996  |  View Paper
In conclusion, octreotide significantly alters glucose tolerance in patients with acromegaly, mandating glucose monitoring during this form of therapy.
European journal of endocrinology  •  1994  |  View Paper
Postprandial glucose rise, between 2 and 3.5 h after breakfast was significantly higher during octreotide than on the control day.
Acta endocrinologica  •  1991  |  View Paper
All received IV dextrose (10–50%) before and after octreotide treatment.
Octreotide significantly increased serum glucose concentrations, decreased dextrose requirement and recurrent hypoglycemic events compared with IV dextrose.
Clinical toxicology  •  2012  |  View Paper
Apical addition of 20 mM D-glucose or D-xylose resulted in a 2.3- or 3.4-fold increased octreotide permeation, respectively.
The Journal of pharmacology and experimental therapeutics  •  1995  |  View Paper
GH levels during octreotide or bromocriptine testing were decreased more significantly in OG responders than in nonresponders (P < 0.05, P < 0.05, respectively).
The Journal of clinical endocrinology and metabolism  •  2019  |  View Paper
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