Possible Interaction: Glucose and Norepinephrine

“ Noradrenaline produced similar reductions in forearm blood flow ratio during glucose and placebo experiments.”

“During stress, plasma norepinephrine and epinephrine concentrations increased by 24% and 44%, respectively, after glucose and by 4% and 21%, respectively, after placebo (n = 6).”

“RESULTS: The plasma noradrenaline concentration response to the glucose load was significantly higher after idazoxan than after placebo administration.”

“TPN with the Glucose System for 4-6 days significantly increased the norepinephrine excretion from 1.95 +/- 0.47 to 6.77 +/- 0.95 microgram/kg/day (P less than 0.01).”

“Blockade of GABAB receptors by p‐(…) attenuated the inhibitory effect of high D‐glucose … [3H]noradrenaline and 5‐[3H]hydroxy‐tryptamine, suggesting that the effect on monoamine release is, at least to a … increased GABA release and, as a consequence, of an increased GABA concentration at inhibitory GABAB receptors.”

“ Glucose values correlated with norepinephrine levels (R2 = 0.39; P = 0.001).”

“Plasma noradrenalin concentration increased significantly (P<0.05) during exercise in the glucose trial , but not in the HBCD trial.”

“Glucagon, norepinephrine , epinephrine and lactate were similar for the morning and evening trials (p>0.05), but the norepinephrine response to the exercise was increased in the morning (+46%, p<0.05), and it was accompanied by a 5-fold increase in the response of glucose.”

“RESULTS: Both therapies resulted in similar decreases in fasting glucose , triglyceride and norepinephrine levels , and they increased the fibrinolytic factor plasminogen but decreased t-PA activity.”

“MSNA and the norepinephrine spillover rate increased from baseline (by 29 +/- 7% and 40 +/- 13%, respectively; P < or = 0.001 for both) in IS subjects after the glucose load.”