Possible Interaction: Glucose and Nifedipine

“10 subjects had normal glucose tolerance; in them nifedipine administration reduced the insulin response to oral glucose in the first 60 min, but improved glucose tolerance.”

“Both diazoxide and nifedipine moderately reduced basal glucose oxidation whereas glucose-induced oxygen consumption (tested with diazoxide) was unaffected.”

“A role for Ca2+ signaling is inferred, since the L‐type Ca2+ channel blocker nifedipine markedly reduces the induction of c‐fos and nur‐77 by glucose and GLP‐1.”

“Because nifedipine blocked the effects of glucose on Ca uptake in the presence of extracellular Na, it was concluded that glucose stimulates reverse Na-Ca exchange.”

“Three weeks following … administration of nifedipine , both glucose and insulin concentrations decreased significantly from 102.1±2.6 to 94.9±2.2 mg/dl and from 19.9±2.9 to 13.9±1.7 µU/ml and also remained significantly lower after 9 weeks of nifedipine therapy.”

“ Glucose infusion rate to restore euglycemia decreased and was discontinued on the 4th to 10th day of nifedipine treatment.”

“These results indicate that in non-diabetic patients, nifedipine reduces the early response of beta-cells to glucose , but this effect is partly compensated by a decreased insulin uptake by the liver.”

“These results prove that in non-diabetic patients nifedipine reduces the early response of the B-cells to glucose , but this effect is partly compensated by decreased insulin uptake by the liver.”

“… nifedipine induced a significant reduction in both systolic and diastolic blood pressures; the infusions of angiotensin II (0.150, …/min, each rate for 30 min) and of potassium chloride (50 mmol in 500 ml of 5% glucose in 50 min) caused similar rises … the administration of the calcium antagonist.”

“The effect of glucose was diminished by nifedipine , a L-type Ca(2+) channel blocker.”