Possible Interaction: Glucose and Nicotine

“ Nicotine caused a small overall reduction in global cerebral metabolism of glucose but, when the data were normalized, several brain regions showed relative increases in activity.”

“As in Exp 1, subjects showed a substantially larger free cortisol response to nicotine under glucose load compared with water load (F = 4.91, P < 0.001).”

“Nature reviews | Endocrinology Nicotine stimulates increases in blood levels of glucose by acting on neurons within the medial habenula, according to a new study published in Nature.”

“the authors found that nicotine , by acting on the medial habenula in a tCF7L2-dependent manner, stimulates increases in blood levels of glucose.”

“Ouabain, dinitrophenol and nicotine strongly inhibited D-glucose uptake in the membrane vesicles.”

“4) The independent inhibitory effects of nicotine and glucose on metabolic yields of DHT were marginally more pronounced in combination but significantly overcome in the presence of insulin.”

“These results suggest that glucose plays a major role in modulating the rewarding effects of nicotine in male rats treated with STZ.”

“ Nicotine is known to affect the metabolism of glucose ; however, the underlying mechanism remains unclear.”

“ResultsThe nicotine pre-exposure (1, 7 & 14 day) resulted in significant reduction in D-glucose influx rate (Kin) across the BBB, with a 49% reduction in 14 day nicotine-infused animals.”

“Concentration of 13C-labeled glutamate-C4 was increased significantly from glucose and acetate with chronic nicotine treatment indicating an increase in glucose oxidation by glutamatergic neurons in all brain regions and glutamate-glutamine neurotransmitter cycle in cortical and subcortical regions.”

“Independent administration of nicotine , or the application of the physical restraint stressor, resulted in increases in the plasma concentrations of corticosterone, epinephrine, norepinephrine, and glucose.”