Possible Interaction: Glucose and Niacin

“ Total glucose uptake during exercise was greater (P <.05) in NA (1,876 +/- 161 micromol.kg(-1)) than in CON (1,525 +/- 107 micromol.kg(-1)).”

“ NA significantly reduced the glucose infusion rate required to maintain euglycaemia in all subjects (placebo vs NA; 31.5 ± 4.2 vs 26.2 ± 4.6 μmol/kg/min, P = 0.002) associated with a decrease in non-oxidative glucose disposal.”

“The short-term administration of a nicotinic acid analogue (acipimox) increases insulin sensitivity and consequently glucose disposal , both in patients with non-insulin-dependent diabetes mellitus (NIDDM) and in patients with cirrhosis.”

“Co-administered with niacin , high-fat meals significantly increased the postprandial concentrations of glucose , insulin, C-peptide, triglycerides, FFAs and postprandial indices of β-cell function.”

“ Nicotinic acid can also increase glucose and uric acid plasma levels.”

“ NA treatment lowered the amount of infused glucose necessary to achieve clamp levels 48 (8) vs. 61 (10) mumol kg-1 min-1 (p < 0.01).”

“values were almost the same for each compound, and that the uptake of D-glucose was competitively inhibited by nicotinamide.”

“… nicotinic acid as a treatment for hyperlipidaemia has been reported to cause glucose intolerance,' a study of schizophrenic patients given nicotinamide in doses of up … problem.^ In view of these facts, we feel that diabetes mellitus should not be an absolute contra-indication for nicotinamide, but that glucose status ….”

“ Glucose infusion after nicotinic acid administration markedly lowered delta Q/delta Vo2.”

“Plasma FFA lowering by nicotinic acid decreased myocardial extraction of FFA and increased that of glucose , lactate, and pyruvate with concomitant increase in myocardial respiratory quotient (RQ).”