Possible Interaction: Glucose and NADH

“To minimize such toxicity, elevated NADH inhibits the classical NADH-producing pathways: glucose , glutamine, and fat oxidation.”

“Both NADPH and NADH were decreased in the presence of 10 mM pyruvate and glucose.”

“In incubation studies, NADP + increased and both NADPH and NADH decreased when medium glucose was omitted.”

“This NADH increase at 1% of baseline reperfusion flow was blocked by removing glucose from the perfusate.”

“Further decreasing the glucose to 0.2 mM gave lower levels of NADH and the redox ratio (40% of control).”

“In … in D-glucose concentration from 2.8 to … augmented (i) the transfer of NADH , presumably via the glycerol phosphate shuttle, into the mitochondria, (ii) the decarboxylation of pyruvate and (iii) the … residues, even when the flow rates were expressed relative to the total rate of D-glucose utilization.”

“These findings and the fact that D-glucose failed to decrease [2-14C]alloxan uptake by the islets suggest that the protective action of D-glucose depends on an increase in the generation rate of reducing equivalents ( NADH and NADPH).”

“ Glucose and glucose metabolites had no effect on Ca-ATPase in the secretory granule fraction from ob/ob mouse islets, whereas NADH inhibited the enzymes by 35%.”

“Both the glucose and fructose diets produced a 2--3-fold increase in total and neutral glycerolipid formation from dihydroxyacetone phosphate measured in the presence of ATP, palmitate, CoA, and NADH.”

“It is suggested that the inhibition of tryptophan pyrrolase activity by glucose or nicotinamide is mediated by both NADPH and NADH.”

“If glucose (3 mg/ml) was present 1 or 10 mM of NAD+ or NADH exhibited a significant effect, NADP+ or NADPH were less effective.”