Possible Interaction: Glucose and NAD

“Underlying mechanisms include NAD+‐ and sirtuin‐mediated deregulation of lipid, glucose and NAD+ homeostasis.”

“Our findings implied that targeting NAD+ could radiosensitize gliomas with GR , and 2-DG administration could be benefit for tumor patients with IDH1 mutation.”

“Levels of the p85-α subunit and reduced nicotinamide-adenine dinucleotide phosphate oxidase subunits, including p47phox, p22phox, and Rac-1, increased in the membrane fraction from arteries treated with d-glucose (20 mmol/L) accompanied by increased intracellular superoxide production.”

“20 mM glucose increased the islet NADH/NAD+ and NADPH/-NADP+ redox ratios as well as islet concentration of ATP and PEP.”

“Finally, measurement of NADH fluorescence showed that addition of glucose (5mm) to a tubule suspension causes an oxidation of NAD.”

“Relative to basal value, D-glucose , in concentrations of 2.8 and 16.7 mM, caused a concentration-related increase in both the NADH/NAD+ and NADPH/NADP+ ratio.”

“ NAD+ inhibited glycation of Lys228 by binding to the enzyme and restricting access to glucose.”

“ D-Glucose increased the cytosolic NADH%/NAD+ ratio (but not the cytosolic NADPH/NADP+ ratio), augmented O2 uptake, raised the ATP/ADP ratio, decreased 86Rb outflow, and stimulated insulin release in tumoral insulin-producing cells of the RINm5Fline, L-Leucine and 4-methyl-2-oxopentanoate also stimulated insulin secretion.”

“The myogenic activity was restituted when glucose was added after withdrawal parallel with a reduction of NAD and flavoproteins.”

“If glucose (3 mg/ml) was present 1 or 10 mM of NAD+ or NADH exhibited a significant effect, NADP+ or NADPH were less effective.”