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Last Updated: 3 months ago

Possible Interaction: Glucose and Misonidazole

supplement:

Glucose

Research Papers that Mention the Interaction

We conclude that cell growth state, glucose , and nonprotein sulfhydryl concentrations affect FMISO binding, albeit less than varying O2 levels: anoxic/oxic binding ratios vary from 12.6 to 28 for the four cell types examined.
Radiation research  •  1990  |  View Paper
In all three cell lines metabolic activation of MISO , as indicated by the binding of 14C-MISO to the acid-insoluble fraction of these cells, was increased by the presence of glucose.
Free radical research communications  •  1987  |  View Paper
However, with 5 mM glucose , after a latent period of 0.5 hours, there was a rapid decrease in cell survival to less than 0.1% at 2.5 hours incubation in 5 mM MISO.
The binding of MISO was also increased by glucose.
International journal of radiation oncology, biology, physics  •  1986  |  View Paper
The stimulatory effect of misonidazole and NDPP on O2 utilization in medium with glucose undoubtedly appeared as a release from the Crabtree effect.
British Journal of Cancer  •  1979  |  View Paper