Possible Interaction: Glucose and Miglitol

“The changing levels of glucose , insulin and triglycerides at 60 min were significantly lower in the miglitol group than in the voglibose and placebo groups (all P<0.01).”

“Reductions in 120-min postprandial glucose and insulin levels were significantly greater in the miglitol group than in the placebo group at all postbaseline visits.”

“The area under the glucose curve was significantly (p less than 0.01) reduced by miglitol although no reduction in fasting blood glucose, HbA1, plasma lipids, insulin dosage or weight was observed.”

“The α-glucosidase inhibitor (α-GI) miglitol is useful for controlling the early postprandial increase of glucose , but the combined effect of miglitol and multiple daily insulin injections (MDI) on glucose excursion has not been evaluated.”

“The category of agents that interfere with the absorption of glucose and lipids includes alpha-glucosidase inhibitors (acarbose and miglitol ) and lipase inhibitors (or-listat).”

“ Miglitol treatment may improve islet sensitivity to glucose either through effects on islet metabolism requiring prolonged exposure or by improvement in postmeal glycemia, despite persistent hyperglycemia.”

“In conclusion, our results show that miglitol administered luminally at the doses employed here, as well as reducing the transport of glucose from the lumen of the intestine into the blood supply, significantly stimulate intestinal glucose metabolism.”