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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glucose
drug:
Metrizamide
Research Papers that Mention the Interaction
“Since the concentration of metrizamide over the cerebral cortex after routine myelography may be approximately 50 mM compared with a glucose concentration of only 3.6 mM (65 mg/dl), it is postulated that impaired brain glucose metabolism may be responsible for some of the toxic effects of metrizamide.”
Asterixis and encephalopathy following metrizamide myelography: Investigations into possible mechanisms and review of the literature“ Metrizamide produces a classical competitive inhibition with glucose for human brain hexokinase, with Kis of 2.8 and 2.5 mM, respectively, for the mitochondrial and soluble forms.”
“It is concluded that, rather than … in the brain cell, metrizamide appears … a net glucose transport into the cell and that this direct effect on the cortex is amplified and propagated, via … of the diencephalon and midbrain, causing secondarily various types of disturbance in the mental and motor functions.”
A possible mechanism for the neural adverse reactions caused by metrizamide.
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