Possible Interaction: Glucose and Methylprednisolone

“ Glucose was significantly … after methylprednisolone treatment at 1 hour after CPB (276 mg/dL v 210 mg/dL; p = 0.001) and at 2 hours (289 mg/… v 213 mg/dL; p = 0.009) and 8 hours (247 mg/dL v 196 mg/dL; p = 0.02) after surgery.”

“Upon binding to GR in liver, MPL dosing caused increased glucose production by stimulating hepatic cAMP and PEPCK activity.”

“Injection of MPL caused temporary increases in glucose over 4 h. Insulin secretion was thereby stimulated yielding a later peak around 6 h. In turn, insulin can normalize glucose.”

“ Methylprednisolone exhibited a dose-response effect in reducing LDH leakage in cultures, which were subsequently deprived of oxygen and glucose for 4 hr.”

“In response to a glucose load (1 g/kg, intravenously) methylprednisolone caused an augmented rise in serum IRI on days 1 and 4, with a later return to or below normal, and an increase in the rate of disappearance and the apparent volume of distribution of glucose.”

“During the intravenous infusion of hydrocortisone or methylprednisolone both the rates of glucose production and utilization fell in normal dogs.”

“In diabetic dogs deprived of insulin, two daily injections of methylprednisolone increased the rate of glucose production and the plasma concentration but not the apparent distribution space of glucose.”

“The intravenous infusion of glucose was found to diminish the rate of endogenous glucose production to the same degree before as after one week of methylprednisolone treatment.”

“per kilogram of methylprednisolone for one week significantly increased the rates of glucose production and utilization and also the amount of intermixing glucose and the apparent glucose space, without any significant change in the concentration of glucose in the blood plasma.”

“After adjustment for gender, history of diabetes mellitus, chronic liver disease, sequential organ … intensive care unit day 1, and length of stay, administration of ≥320 mg methylprednisolone equivalent was associated … spent with glucose either <80 mg/dL or >180 mg/dL (…, 95% CI = 2.15-5.85, P < .001).”

“diluent, followed by initial free methylprednisolone percentage and pH. Consistently higher turbidity values at most methylprednisolone concentrations were recorded in 5% dextrose injection.”