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Discover Supplement-Drug Interactions
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Last Updated: 5 months ago
supplement:
Glucose
drug:
Methotrexate
Research Papers that Mention the Interaction
“ MTX treatment was also associated with a significant reduction of glucose and insulin serum concentrations in diabetic mice (P < 0.001), and glucose levels only (P < 0.05) in controls.”
Methotrexate Increases Skeletal Muscle GLUT4 Expression and Improves Metabolic Control in Experimental Diabetes“On the other hand, amethopterin decrcased the coulombic output from glucose.”
“The preccnt depression of columbic output of glucose by amethopterin was found to be equivalent to the extent to which glucose is reported to be metabolized via the shunt pathway.”
“The injection of sarcolysine, methotrexate , thiophosphamide, cyclophosphamide, adryamycin and platidinum during glucose infusion is shown to increase their antitumour activity.”
[Induced hyperglycemia as a factor of modification of sarcoma 45 sensitivity to chemotherapy].“1 hour prior to methotrexate prevented the inhibition of transmucosal transport of both glucose and tyrosine.”
“Administration of glucose (0.5/g/kg. i/p.) 1 hour prior to methotrexate prevented the inhibition of transmucosal transport of both glucose and tyrosine.”
“ Glucose also reduced the body weight loss caused by methotrexate.”
“The data suggest that coadministration of glucose with methotrexate may have a potential clinical value, since glucose may alleviate the toxic effects of methotrexate in patients receiving this drug.”
“ Glucose release from endogenous glycogen (glycogenolysis) is strongly activated by methotrexate.”
“ MTX significantly suppressed the maximal uptake rate of glucose (Vmax) while addition of dThd alleviated the suppression.”
“Methotrexate MTX ) suppressed the growth of Ehrlich ascites tumor cells in vivo and reduced the cellular uptake of glucose and the density of glucose transporters on the tumor cell surface.”
“Using the everted sac technique, the rates of D-glucose and L-tyrosine transport were decreased by MTX to 10.9 and 6.3 mumol/g/h from control values of 35.0 and 10.0 mumol/g/h, respectively.”
“However, glucose or azide increased the fraction of dihydrofolate reductase associated with methotrexate and abolished the effect of tetrahydrofolates on this intracellular component.”
“ Glucose (which increases ATP levels) reduces influx rates and steady-state levels of MTX , and induces efflux in both PBS and Hepes-Mg.”
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