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Discover Supplement-Drug Interactions
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Last Updated: 6 months ago
supplement:
Glucose
drug:
Methotrexate
Research Papers that Mention the Interaction
“ Parenteral glucose feeding produced a protective effect on the isolated liver against the detrimental action of both methotrexate and cyclophosphamide.”
[Effect of fasting and elemental carbohydrate feeding on the liver resistance to the action of cytostatics].“The injection of sarcolysine, methotrexate , thiophosphamide, cyclophosphamide, adryamycin and platidinum during glucose infusion is shown to increase their antitumour activity.”
“1 hour prior to methotrexate prevented the inhibition of transmucosal transport of both glucose and tyrosine.”
“ Glucose also reduced the body weight loss caused by methotrexate.”
“The data suggest that coadministration of glucose with methotrexate may have a potential clinical value, since glucose may alleviate the toxic effects of methotrexate in patients receiving this drug.”
“ Glucose release from endogenous glycogen (glycogenolysis) is strongly activated by methotrexate.”
“ MTX significantly suppressed the maximal uptake rate of glucose (Vmax) while addition of dThd alleviated the suppression.”
“Methotrexate MTX ) suppressed the growth of Ehrlich ascites tumor cells in vivo and reduced the cellular uptake of glucose and the density of glucose transporters on the tumor cell surface.”
“Using the everted sac technique, the rates of D-glucose and L-tyrosine transport were decreased by MTX to 10.9 and 6.3 mumol/g/h from control values of 35.0 and 10.0 mumol/g/h, respectively.”
“However, glucose or azide increased the fraction of dihydrofolate reductase associated with methotrexate and abolished the effect of tetrahydrofolates on this intracellular component.”
“ Glucose (which increases ATP levels) reduces influx rates and steady-state levels of MTX , and induces efflux in both PBS and Hepes-Mg.”
“Our results demonstrate that the conjugation of MTX to glucose led to an increase in potency against malignant cells under oxygen and nutrient stress.”
Overcoming Hypoxia-Induced Chemoresistance in Cancer Using a Novel Glycoconjugate of Methotrexate
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