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Possible Interaction: Glucose and Methotrexate

supplement:

Glucose

Research Papers that Mention the Interaction

Parenteral glucose feeding produced a protective effect on the isolated liver against the detrimental action of both methotrexate and cyclophosphamide.
Gematologiia i transfuziologiia  •  1990  |  View Paper
The injection of sarcolysine, methotrexate , thiophosphamide, cyclophosphamide, adryamycin and platidinum during glucose infusion is shown to increase their antitumour activity.
Eksperimental'naia onkologiia  •  1987  |  View Paper
1 hour prior to methotrexate prevented the inhibition of transmucosal transport of both glucose and tyrosine.
Glucose also reduced the body weight loss caused by methotrexate.
The data suggest that coadministration of glucose with methotrexate may have a potential clinical value, since glucose may alleviate the toxic effects of methotrexate in patients receiving this drug.
Drug-nutrient interactions  •  1987  |  View Paper
Glucose release from endogenous glycogen (glycogenolysis) is strongly activated by methotrexate.
Research communications in chemical pathology and pharmacology  •  1986  |  View Paper
MTX significantly suppressed the maximal uptake rate of glucose (Vmax) while addition of dThd alleviated the suppression.
Pharmacological research communications  •  1986  |  View Paper
Methotrexate MTX ) suppressed the growth of Ehrlich ascites tumor cells in vivo and reduced the cellular uptake of glucose and the density of glucose transporters on the tumor cell surface.
Cancer biochemistry biophysics  •  1986  |  View Paper
Using the everted sac technique, the rates of D-glucose and L-tyrosine transport were decreased by MTX to 10.9 and 6.3 mumol/g/h from control values of 35.0 and 10.0 mumol/g/h, respectively.
Toxicology  •  1985  |  View Paper
However, glucose or azide increased the fraction of dihydrofolate reductase associated with methotrexate and abolished the effect of tetrahydrofolates on this intracellular component.
Cancer research  •  1983  |  View Paper
Glucose (which increases ATP levels) reduces influx rates and steady-state levels of MTX , and induces efflux in both PBS and Hepes-Mg.
Archives of biochemistry and biophysics  •  1980  |  View Paper
Our results demonstrate that the conjugation of MTX to glucose led to an increase in potency against malignant cells under oxygen and nutrient stress.
Pharmaceuticals  •  2020  |  View Paper
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