Possible Interaction: Glucose and Melatonin

“As a regulatory mechanism, melatonin reduces the uptake of glucose and modifies the expression of GLUT1 transporter in prostate cancer cells.”

“Insulin release from clonal β cells in response to glucose was inhibited in the presence of melatonin.”

“In the morning, the effect of melatonin (melatonin-placebo) on the glucose area under the curve (AUC) above baseline differed significantly (P=0.036) between the carriers and noncarriers.”

“In the patients with MS unlike the controls the night–day melatonin difference (%) correlated negatively with the fasting glucose (r = −0.494, p = 0.023) and positively to daily insulin (r = +0.536, p = 0.012).”

“At melatonin concentrations of 10 - … for 48 hours, melatonin significantly increased the insulin protein level in INS-1E cells above the level in … without melatonin or glucose treatments and decreased the insulin level in media with glucose : increases in insulin synthesis and decreases … secretion occurred in dose-dependent manners.”

“ Melatonin and its metabolites have been demonstrated to modulate the glucose , dyslipidemia and other metabolic disorders.”

“ Melatonin (200 pmol·crab−1) increased the levels of glucose and lactate in crabs exposed to 6 mgO2·L−1, and luzindole (200 nmol·crab−1) decreased this effect, indicating that melatonin receptors are involved in hyperglycemia and lactemia.”

“Studying insulin-dependent inhibition of glucagon-activated glucose production showed that melatonin (50 µM), used as ROS scavenger, inhibited ROS formation and blunted the effect of insulin on glucose production.”

“ Melatonin caused a marked decrease of insulin secretion by islets in response to glucose.”

“ Melatonin caused a shift in the glucose and lactate cycles, with only one peak occurring closer to mid-photophase.”