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“While the effects of AA were insensitive to cyclooxygenase inhibition, the lipoxygenase inhibitor, nordihydroguaiaretic acid , substantially blocked the AA effect on basal glucose uptake.”
The Journal of Biological Chemistry • 2001 | View Paper
“This effect, like that of glucose , was blocked by nordihydroguaiaretic acid , a selective inhibitor of the lipooxygenase metabolic pathway, but not by inhibitors of the cyclooxygenase or cytochrome P450-monooxygenase pathways.”
The Journal of biological chemistry • 1999 | View Paper
“The lipoxygenase inhibitors BW755C and nordihydroguaiaretic acid inhibited [3H]InsP production in response to glucose , carbamylcholine, and fatty acids.”
“ NDGA given alone in the presence of stimulatory concentrations of glucose suppressed the normal eight-fold rise in insulin secretion, but caused a marked enhancement in glucagon secretion that could be overcome by simultaneous inclusion of flurbiprofen.”