Possible Interaction: Glucose and Magnesium

“Moreover, intracellular magnesium may play a crucial role in modulating B-cell response to glucose by interfering with potassium permeability.”

“ Magnesium also influences glucose and insulin homeostasis, and hypomagnesemia is associated with metabolic syndrome.”

“In vitro it was shown that glucose , in a specific, dose- and time-dependent manner, can directly and coordinately alter intracellular ions, increasing cytosolic free calcium, while suppressing intracellular free magnesium and pH levels.”

“TDP also requires magnesium to achieve activation of TDP dependent enzymes, including transketolase (TK), pyruvate dehydrogenase (PDH) and alpha-keto glutaric acid dehydrogenase (AKGDH), during metabolism of glucose.”

“OBJECTIVE Higher intake of magnesium appears to improve glucose and insulin homeostasis; however, there are sparse prospective data on the association between magnesium intake and incidence of type 2 diabetes.”

“Our data supports the hypothesis that glucose per se induces a substantial decrease in intracellular ionized magnesium , which is probably due to an augmented binding of intracellular ionized magnesium to cellular ATP.”

“Finally, when the 18 patients were analyzed together, there were significant (P < 0.05 to P < 0.01) inverse correlations between Mg concentrations and glucose (r = -0.68) and insulin (r = -0.51) areas and SSPG concentrations (r = -0.60).”

“The renal clearances of Mg and glucose were positively correlated (r = 0.56; p < 0.01), with a steeper slope in recurrent calcium urolithiasis than controls.”

“In conclusion, renal tubular reabsorption of Na, K and Cl was enhanced, while that of Ca and Mg was inhibited after glucose ingestion in both CGN and DM patients.”

“… magnesium insulin prior to a test breakfast in people with Type 2 … lower total and 0 to 120 min areas under the glucose curve , an earlier rise in exogenous insulin levels and a higher area under the … to 120 min compared with unmodified 100 U ml−1 human insulin.”