Possible Interaction: Glucose and Lysine

“Taken together, these findings suggest that GR induces posttranslational modifications of lysines within mutant p53 proteins, which subsequently target them for autophagy-dependent degradation.”

“However, alongside this indispensable role for cell survival and growth, glucose is intrinsically toxic by reacting with primary amines such as lysine in proteins in a non-enzymatic glycation process (a.k.a.”

“The purified preparation of pyrraline obtained from the reaction of glucose with lysine when stored at room temperature or at refrigeration turned pink in color, suggesting spontaneous formation of degradation products.”

“Background: Lysine is reported to lower the glycemic response to oral glucose in humans and, albeit at high loads, to slow gastric emptying of glucose and decrease food intake in rats.”

“The glucose group had significantly higher concentrations of asparagine, glutamine, glycine, alanine, and lysine after treatment.”

“In one such motif, called glucosepane, the side chains of lysine and arginine form a condensed cross-link through a reaction sequence with glucose.”

“Lysine alone increased the insulin area response modestly; the insulin increase when lysine was ingested with glucose was similar to that when only glucose was ingested.”

“When lysine was ingested with glucose , the 2.5-h glucose area response decreased by 44% (P < 0.02).”

“In Diabetes Mellitus (DM), glucose and the aldehydes glyoxal and methylglyoxal modify free amino groups of lysine and arginine of proteins forming advanced glycation end products (AGEs).”

“On the other hand, a significant improvement in the F-actin organization was observed in the cells co-incubated with 25 mM glucose and lysine.”

“In vitro incubation of serum total protein (TP), albumin (ALB), gamma-globulin (GLB), free lysine Lys ), and free valine (Val) with glucose at different concentrations of Pi showed a Pi-dependent increase of FRA synthesis throughout 48 h of incubation.”