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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“ losartan … glucose metabolic clearance rate by 5.1 ± 0.3 and 6.3 ± 0.4 mg/kg × min (P < 0.05), and whole body glucose disposal (….5 and 38.1 ± 0.4 μ mol/kg free fatty mass (FFM) × min (P < 0.01) but did not affect heart rate.”
Losartan mediated improvement in insulin action is mainly due to an increase in non-oxidative glucose metabolism and blood flow in insulin-resistant hypertensive patients“ Dextrose induced ER stress was reduced with pharmacologic blockers of AT1 ( losartan and candesartan) and mineralocorticoid receptor blocker (spironolactone) but not with angiotensin converting enzyme inhibitors (captopril and lisinopril).”
“We found that 33 urinary metabolites were significantly changed in DM …, and the levels of 16 metabolites among them, namely, glucose , mannose, myo-inositol, pyruvate, fumarate, 2-hydroxyglutarate, isobutyrate, glycine, threonine, dimethylglycine, methyldantoin, isoleucine, leucine, …-3-methylglutarate, and taurine, shifted closer to the control level in response to losartan ….”
Urinary Metabolomic Profiling in Streptozotocin-Induced Diabetic Mice after Treatment with Losartan“High glucose increased anti-GBM binding compared with normal glucose; this effect of glucose was reversed by losartan.”
“ Losartan fully inhibited COX-2 protein responses to AngII and mannitol, but minimally inhibited responses to glucose.”
Stimulation of Cyclooxygenase 2 Expression in Rat Peritoneal Mesothelial Cells
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