Possible Interaction: Glucose and Long Chain Fatty Acid

“Background: Hypothalamic long-chain fatty acids LCFA ) and glucose are critical for energy balance, but it is not known if their metabolism is coupled.”

“The observations suggest that a significant part of glucose is perhaps diverted to long-chain fatty acids , etc.”

“IN physiological concentrations, circulating long chain free fatty acids (FFA) can inhibit the myocardial oxidation of glucose and are the preferred fuel of the heart in the fasted state1,2.”

“In contrast to the findings with short chain fatty acids, liver slices from cold-fasted rats show no defect in … chain fatty acids, i.e. palmitate-1-CY4, stearate-1-V and oleate-1-V. Furthermore, the addition of glucose to th; incubation … of the long chain fatty acids ….”

“On the other …, the addition of glucose to the liver slices from the control rats (fed and maintained at 25”) results in a reduction in the oxidation of the long chain fatty acids , a manifestation of the well known sparing action of glucose on oxidation of long chain acids.”

“In other words, LCFAs do not trigger insulin release by themselves but strongly amplify the stimulating effect of glucose (1).”

“Conclusions: The addition of nutrient substrate, such as lucose and cysteine could decrease the toxicity of L CFA on anaerobic granulation.”

“When present in the medium, glucose stimulated the degradation of long-chain fatty acids by increasing the rate of uptake and the level of acyl-CoA synthetase.”

“In a study of flagellar biogenesis in Salmonella typhimurium and Escherichia coli, it was found (41 that benzoate and long-chain fatty acids relieved the catabolite repression of flagellum formation caused by growth on glucose.”