Possible Interaction: Glucose and Levodopa

“Variation in the mode of administration of L-dopa , shown in a previous study to affect its absorption, caused differences in the rate and magnitude of increase in plasma FFA and glucose.”

“Addition of 100 g glucose orally to the L-dopa completely abolished the GH response of both groups.”

“Perhaps the oral administration of L-dopa alone causes an alteration in some gastrointestinal functions which are involved in the handling of oral glucose.”

“ oral glucose with the L-dopa , or thirty minutes thereafter, totally suppressed the growth hormone response in all eight and six of the subjects, respectively.”

“The fact that the … growth hormone rise after L-dopa administration is suppressible by glucose , as in other “daily life” plasma growth hormone-induced rises, suggests, but does not prove, that dopamine plays and important role in the normal regulation of the growth hormone release from the pituitary gland.”

“The addition of glucose (8.4–18.4 mM) to the incubation medium decreased about 40% the uptake of L-dopa by isolated proximal tubular cells.”

“The L-DOPA was shown to hinder the absorption rate of glucose , whereas sulpiridinum was shown to suppress the main enzymes excepting snerase and alkaline phosphatase, to increase the monomeric and hydrolysate glucose transport.”

“ L-DOPA (125 or 250 pmol/kg), given together with glucose , induced a decrease in glucose-induced insulin response.”

“ L-DOPA (125 pmol/kg), given 7 min before glucose , totally suppressed glucose-induced insulin response.”

“Infusion of L-dopa (20 mg/kg/h) increased glucose production causing hyperglycemia.”