Possible Interaction: Glucose and Leucine

“Net leucine balance during the clamp correlated with rates of glucose disposal.”

“A correlation between the rate of appearance of leucine and glucose was observed (r = 0.755, P < 0.001).”

“In muscle both the leucine infusion and the leucine plus glucose infusion increased the concentration of free leucine significantly, while the sum of the other branched chain amino acids (BCAA), of the aromatic amino acids and of the basic amino acids decreased.”

“The combination of leucine and glucose had an additive effect.”

“Meanwhile, global disturbance of branched-chain amino acid (BCAA) metabolism was detected, and the change of BCAA leucine ) was positively correlated to the alteration of glucose.”

“We further show that leucine facilitated the insulin-mediated suppression of glucose production and expression of key gluconeogenic genes in a Gαi1 protein-dependent manner in cultured primary hepatocytes.”

“In addition to catabolite repression by glucose, l-leucine acts by inhibiting the binding of Lrp to the promoter region, hence preventing transcription of the TonB3 operon.”

“Optimal concentration of glucose (11 mM) activated six- to sevenfold the [3H]leucine incorporation into IRI.”

“ Leucine exhibits strong insulinotropic characteristics, which may increase amino acid availability for muscle protein synthesis, reduce muscle protein breakdown, and enhance glucose disposal to help maintain blood glucose homeostasis.”

“ Leucine also attenuated the decrease in glucagon expected when glucose alone is ingested.”

“When leucine was ingested with glucose , it attenuated the serum glucose response and strongly stimulated additional insulin secretion.”

“When leucine was ingested with glucose , it reduced the 2.5-hour glucose area response by 50%.”

“Whereas total protein is important in providing substrates for gluconeogenesis, leucine appears to regulate oxidative use of glucose by skeletal muscle through stimulation of glucose recycling via the glucose-alanine cycle.”