Possible Interaction: Glucose and Leptin

“Plasma leptin levels remained constant at glucose concentrations between 5.8-6.5 mmol/liter, which … normoinsulinemia at 41.5-45.4 pmol/liter and FFA at 106-123 mg/liter, but leptin concentrations were increased … higher rates of glucose infusion (with plasma glucose rising … 8.7 mmol/liter).”

“A continuous intravenous infusion of 5% glucose providing 1414 +/- 323 kJ/d (338 +/- 78 kcal/d) was begun after … of fasting in seven subjects who continued to fast for an additional 6 d. Within 24 h of the glucose infusion, leptin concentrations increased significantly by … +/- 52% (P < 0.05).”

“Recent Findings Leptin deficiency is associated with insulin resistance and impaired glucose metabolism whereas leptin administration improves tissue glucose uptake/oxidation and reduces hepatic glucose output.”

“Major conclusions Leptin exerts a plethora of metabolic effects on various tissues including suppressing production of glucagon and corticosterone, increasing glucose uptake, and inhibiting hepatic glucose output.”

“ Leptin triggers signaling events with significant transcriptional responses that are essential to metabolic processes affecting obesity and glucose disposal.”

“Sheep receiving central leptin showed improvements in glucose tolerance and circulating insulin levels after an iv glucose load.”

“Besides its well known effects on food intake and energy metabolism, leptin has been shown to regulate cardiovascular function, glucose and lipid metabolism.”

“Co-administration of IFNalphaA/D + leptin significantly reduced plasma cholesterol (P<0.001), glucose (P<0.007) and pro-apoptotic protein levels (P<0.05).”

“ Leptin also decreases glucose and stimulates lipolysis through central and peripheral pathways involving AMP‐activated protein kinase (AMPK).”

“Insulin and glucose appear to increase leptin secretion.”

“ Leptin increases skeletal muscle glucose uptake and oxidation, and suppresses hepatic glucose output.”