Possible Interaction: Glucose and Isoproterenol

“An intravenous infusion of isoprenaline (1 mug/kg/mn during 4 h) elicited a rise in serum free fatty acids (FFA) and glucose in anaesthetised cats.”

“The degree of suppression induced by glucose was significantly higher than that achieved by isoproterenol.”

“ Isoproterenol infusion alone significantly suppressed GHRH-induced GH secretion and augmented the inhibitory action of glucose on GH release.”

“A high concentration of glucose in the adipocyte culture promoted the basal rate of glycerol release and significantly enhanced the lipolytic action stimulated by either TNF-alpha or isoproterenol.”

“ Oral glucose increased the concentration of PP from … (14.1-141.7) pM. Isoprenaline increased the PP concentration from 13.5 (4.6-33.8) to 56.0 (5.7-137.3) ….3-134.7) pM. The increase in PP concentration was eliminated when propranolol was added to isoprenaline.”

“The infusion of isoproterenol resulted in a 30–35% increase in glucose production (P < 0.025) which remained at levels significantly above baseline ...”

“ Glucose enhanced the basal lipolysis and potentiated significantly the adipokinetic effects of noradrenaline, isopropylnoradrenaline and N6-2′0-dibutyryl cAMP (dibutyryl cAMP).”

“ Isoproterenol induces elevations of plasma FFA and glucose which are reduced by DCI (4 mg kg).”

“These results support the notion that ISO acutely accelerates oxidative metabolism of glucose to meet the ATP demand required to support increased heart rate and cardiac output.”

“Furthermore, this reduction effectively blunted the capacity of glucose and isoprotereonol to synergistically induce hypertrophic gene expression and cell size expansion.”