Possible Interaction: Glucose and Inulin

“Determination of plasma inulin , especially at low levels, showed substantial interference by glucose.”

“Apart from the intestinal environment, inulin induces physiological effects, which includes a reduction in glucose and lipid concentrations and modulation of gastrointestinal motility through the release of different peptides.”

“Since glucose can interfere with the assay of inulin , the sample must be treated with NaOH prior to the determination of the inulin concentration.”

“However, the dietary inulin supplementation after weaning increased the ΔIsc (P<0.001) compared with the controls, suggesting that the inulin supplementation increased the electrogenic transport of glucose across the jejunal mucosa of weaned piglets indicating higher glucose absorption.”

“These findings suggest that caution needs to be exercised when using glucose or dextran and when inulin is quantitated using this method.”

“ Inulin administration during 12 days caused five-fold increase of blood fructose compares with control, glucose level increased up to the level of uncurred diabetes (22 mmol/1), glucose- and ketoneuria appeared.”

“Chicory extract or inulin in the perfusate (10 g/L) inhibited the absorption of glucose from jejunum (P < 0.05).”

“During infusion of glucose , there was a significant (P less than 0.05) time-dependent reduction in inulin clearance indicating that IV glucose administration may be inappropriate in goats with compromised renal function.”

“In rats infused with glucose in saline inulin clearance increased significantly during the 4-6 h period compared with that during the 2-4 h period (4.14 +/- 0.32 vs 3.31 +/- 0.32 ml/min, p less than 0.05 paired t-test).”

“The use of 4.25% dextrose dialysate for three exchanges produced approximately a 50% increase in urea and inulin clearances.”