Possible Interaction: Glucose and Intralipid

“In IGT relatives, the beta-cell responsiveness to glucose (measured during DORE) decreased after 2 and 24 hours Intralipid infusion (P=.02), whereas first phase insulin response (measured during IVGTT) decreased after 24 hours Intralipid infusion.”

“Insulin sensitivity as assessed by the amount of infused glucose and its ratio to insulin was enhanced by Intralipid after an overnight fast, but was decreased after a 58 h fast.”

“RESULTS Intralipid infusion reduced whole-body glucose infusion rate by 26% in women and 38% in men (P < 0.05), and insulin-stimulated leg glucose uptake was reduced significantly less in women (45%) than men (60%) after intralipid infusion.”

“Recent studies in our laboratory … and alternate infusions of glucose … Intralipid in rats impair insulin gene expression, providing evidence that inhibition of the insulin gene under glucolipotoxic conditions is an … indeed contribute to beta-cell failure in Type 2 diabetes, although this hypothesis remains to be tested in humans.”

“When coinfused with Intralipid into the duodenum, glucose markedly stimulated TRL-apoB48 production (P<0.01), with a concomitant moderate increase in fractional clearance (P<0.05), resulting in net elevation of TRL-apoB48 concentration.”

“ Glucose infusion rate and leg glucose uptake was decreased by intralipid.”

“Combined Intralipid and dextrose infusion resulted in endothelial dysfunction similar to Intralipid alone.”

“Our conclusion was that Intralipid enhanced glucose production by increasing gluconeogenesis in preterm infants.”

“With Intralipid, forearm glucose uptake decreased during euglycemia but not during hyperglycemia (+3.85 +/- 0.34 vs. +3.34 +/- 0.25 mumol.100 ml forearm-1.min-1, EC vs. EL, P less than 0.02), with comparable changes in whole body glucose uptake.”

“Intralipid infusion increased mean plasma free fatty acid concentrations from 0.… +/- 0.08 to 1.12 +/- 0.09 (SE) mM. Thigh glucose uptake during rest, exercise, and recovery was … by 64, 33, and 42%, respectively, by Intralipid , whereas muscle glycogen breakdown and release … lactate, pyruvate, and citrate were unaffected.”