Possible Interaction: Glucose and Interferons

“RESULTS Gl cose st imulates int erferon γ ex pression and activates Janus kinase 2/signal transducers and activators of transcription 4 signaling pathway in Jurkat E6-1 cells in a concentration and time-dependent manner.”

“… glucose … IFN-α2a to 4.9×106 from 3.1×106 IU/mL. When adenine was added evenlly for 10–20 h of fermentation into the … ethanol generated was also reduced tremendously during the process and as a result, 1.3×107 IU/mL of biologic activity was achieved.”

“In the OGT test, the area under the glucose curve was 2.6-fold greater (P < .02), and the disappearance rate of intravenously administered glucose was reduced by 28% (P < .05) after IFN administration.”

“Furthermore, expression of a TLR4 downstream signaling cascade including myeloid differentiation factor 88 (MyD88), interferon regulatory factor 3 (IRF3), and Toll interleukin receptor domain containing adaptor inducing interferon-β (TRIF)-related adaptor molecule (TRAM) were significantly increased in cells exposed to 25 mM glucose (P < 0.05).”

“Furthermore, glucose decreased the extent of induction of 2',5'-oligoadenylate synthetase by IFN.”

“ Glucose was found to impair the antiviral activity of rabbit interferon (IFN) in RK-13 cells.”

“However, the specific rate of IFN‐γ production was significantly lower at the higher glucose feed concentration.”