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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glucose
drug:
Insulin Glargine
Research Papers that Mention the Interaction
“Circadian fluctuation of glucose assessed by M-value showed a significant decrease after glargine treatment (p < 0.003).”
Comparison of glucose variability assessed by a continuous glucose-monitoring system in patients with type 2 diabetes mellitus switched from NPH insulin to insulin glargine: The COBIN2 study“Also, the fasting plasma glucose or post-prandial 2 h glucose were comparably decreased in dapagliflozin or insulin glargine.”
“The basal bolus regimen with glargine significantly reduced HbA1c (Mean Difference, MD=2.27, CI [1.76, 2.78]), fasting glucose (MD=5.15, CI [4.86, 5.44]) and 2-hours postprandial glucose concentration (MD=6.94, CI [6.53, 7.34]).”
“Treatment with glargine was associated with lower fasting glucose values than treatment with detemir (8.1±1.5 vs. 8.2±1.7 mmol/L, p=0.01).”
“CONCLUSION A single subcutaneous injection of glargine at a dose of ≥0.5 units/kg can acutely reduce glucose , NEFA, and ketone body levels for 24 h in obese insulin-resistant type 2 diabetic individuals.”
“ Glargine exhibited a relatively hepatospecific action with greater suppression (P < 0.05) of endogenous glucose production (EGP) compared with little or no increases in glucose disposal.”
“… insulin glargine resulted in … SD of glucose values (adjusted mean change from baseline to week 24: −13.4 mg/dl [−0.74 mmol/l]; P ≤ 0.05), mean amplitude ….91 mmol/l]; P ≤ 0.0001), and M value (−9.6 mg/dl [−0.53 mmol/l]; P ≤ 0.03).”
“Area under the curve for glucose >7 mmol/l was reduced by 61% by Lantus (p <0.001).”
“The rate of confirmed glucose values <70 mg/dL was higher in the patients receiving insulin glargine (P = .0298).”
“Subjects on IG increased insulin doses until fasting glucose was <120mg/dl.”
“ Fasting glucose decreases were significantly greater with glargine (-2.6+/-2.4 mmol/l) than with lispro or MidMix (-0.9+/-2.2 mmol/l; +0.9+/-1.8 mmol/l).”
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