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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glucose
drug:
Indomethacin
Research Papers that Mention the Interaction
“The stimulation of glucose production coincided with the inhibition of insulin secretion by 52% within 1 hour after administration of indomethacin (P < .001).”
Indomethacin decreases insulin secretion in patients with type 2 diabetes mellitus.“ Indomethacin administration … glucose production from 10.9 (SEM 0.3) mumol min-1 kg-1 to a maximum of 16.5 (SEM 1.6) mumol min-1 …) within approximately 1 h, whereas in the control experiment glucose production declined gradually (P < 0.01) (P < 0.05 indomethacin versus control).”
“Since indomethacin administration resulted in an increase in glucose production in the absence of any changes in concentrations of glucoregulatory hormones, we conclude that indomethacin stimulates hepatic glucose production through other mechanisms.”
“The different concentrations of indomethacin decreased FN and PAI-1 secretion in the 2.5% glucose or the LPS group within 24 h (P < 0.05).”
“It has been suggested that early metabolic events leading to the permeability changes may involve inhibition of glycolysis and the tricarboxylic acid cycle, in which case the coadministration of glucose and citrate (the substrates for these metabolic pathways) with indomethacin may afford some protection.”
“By comparing the results with untreated control patients, it was found that the peak blood level of glucose , and the serum level of insulin-like activity, could be significantly decreased by this oral administration of indomethacin.”
“ Indomethacin interfered in glucose , urea, uric acid and protein assays.”
“In the presence of indomethacin, glucose infusion caused a quadratic 9% increase in IPF.”
Mammary blood flow and metabolic activity are linked by a feedback mechanism involving nitric oxide synthesis.“In addition, both 16,16-dmPGE2 and glucose infusion afforded a significant protection against gastric lesions induced by indomethacin even in the acid-perfused stomach (150 mM HCl).”
“The blockade of the eicosanoid production by indomethacin and caffeic acid drastically increased the glucose release and the colloidal carbon uptake in controls and, in absolute terms, to a lesser extent in cirrhotic livers.”
“ Indomethacin (5 x 10(-6) M) increases the metabolism of labelled glucose in all experimental groups, significantly.”
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